Tesofensine: Research Profile, Dosages & Supplier Prices
Tesofensine is a metabolic research (small molecule) compound with a molecular weight of 328.3 g/mol and a research half-life of ~8-9 days (very long). Tesofensine is a triple monoamine reuptake inhibitor - blocking serotonin, norepinephrine and dopamine reuptake - originally developed for Parkinson's and Alzheimer's disease. During those trials researchers noticed substantial, dose-dependent weight loss, and development pivoted to obesity, where Phase 2 data showed weight loss roughly double that of then-available medications.
Research Use Only (RUO). Not for human or veterinary use. Not medical advice.
| Sequence | Non-peptide small molecule |
| Formula | C17H23Cl2NO |
| Mol. weight | 328.3 g/mol |
| Half-life | ~8-9 days (very long) |
| Forms sold | Powder (oral small molecule) |
What is Tesofensine?
Its weight-loss effect comes from combined appetite suppression and increased energy expenditure and fat oxidation, driven by the triple neurotransmitter action. Though not a peptide, it is a staple of metabolic research catalogs and is frequently studied alongside GLP-1 agonists as a mechanistically distinct (central monoaminergic vs incretin) approach. The very long half-life of over a week is a defining pharmacokinetic feature.
Mechanism of Action (Research Context)
Triple reuptake inhibitor of serotonin, norepinephrine and dopamine transporters (SERT/NET/DAT). Central appetite suppression plus increased thermogenesis and fat oxidation; dopaminergic action modulates food reward pathways.
Research Areas
Tesofensine Dosages in Research
Phase 2 obesity trials used 0.25-1 mg once daily. Microgram-to-milligram compound with ~8-9 day half-life. Research-context only.
Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.
Storage & Handling
Powder: room temperature desiccated or 2-8C, protected from light. Stable small molecule.
Tesofensine Supplier Price Comparison
| Supplier | Product | Price | Score |
|---|---|---|---|
| Arctic Peptides | Tesofensine | — | ★ 1.5 |
| Behemoth Labz | Tesofensine | — | ★ 3.2 |
| Wholesale Medical Supplies for Clinics & Practitioners | Tesofensine | $85.00 | ★ 2.8 |
| Fatburner online kaufen im Onlineshop von Fatburners.at | Swiss Pharmaceuticals TESOFENSINE | $89.90 | ★ 3.2 |
| Ascend BioHealth | Tesofensine | $90.00 | ★ 1.9 |
| Home | TESOFENSINE CAPSULES 500MCG 500mcg | $114.99 | ★ 1.7 |
| One moment, please... | Tesofensine | $119.00 | ★ 2.4 |
| Research Materials | Tesofensine | $140.00 | ★ 1.7 |
| Pepsules™ | Tesofensine Capsules | $145.00 | ★ 1.7 |
| Research Peptides & Laboratory Materials | Tesofensine 500mcg 500mcg | $150.00 | ★ 2.6 |
| Alpha Omega Peptides: Buy High | Tesofensine 500mcg 500mcg | $150.00 | ★ 2.3 |
| Buy Alpha Omega Peptides | Tesofensine 500mcg 500mcg | $150.00 | ★ 2.3 |
| Alpha omega peptide | Tesofensine 500mcg 500mcg | $150.00 | ★ 2.3 |
| Certified | TESOFENSINE 500 MCG 60 CAPSULES 500mcg | $160.00 | ★ 9.8 |
| Research Peptides | Tesofensine Capsules – 500mcg 500mcg | $200.00 | ★ 2.0 |
| LUXE AMINOS | TESOFENSINE 500mcg (120 count) MAXIM – Bottle of 3 500mcg | $550.00 | ★ 2.8 |