Follistatin 344: Research Profile, Dosages & Supplier Prices

Growth factor research · Lyophilized powder · Also known as: FST344, FS344, Activin-binding protein

Follistatin 344 is a growth factor research compound with a molecular weight of ~37.8 kDa and a research half-life of hours to days (isoform-dependent). Follistatin 344 is the full-length splice isoform of follistatin, a secreted glycoprotein best known as a high-affinity binding and neutralizing protein for myostatin (GDF-8) and other TGF-beta family ligands including activins. Myostatin is the body's primary brake on muscle growth, which makes follistatin one of the most studied targets in muscle-wasting and muscle-hypertrophy research.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	344-aa glycoprotein (FST344 splice isoform of follistatin)
Formula	Glycoprotein (variable glycosylation)
Mol. weight	~37.8 kDa
Half-life	Hours to days (isoform-dependent)
Forms sold	Lyophilized powder

What is Follistatin 344?

Animal studies with follistatin overexpression or gene therapy have produced dramatic increases in muscle mass, and a follistatin gene-therapy approach has entered early human trials for muscular dystrophies. Recombinant FST344 sold by peptide suppliers is used in cell and animal research on myostatin/activin signaling, reproductive biology (it was first isolated from follicular fluid), and metabolic regulation. As a large glycoprotein it is expensive to manufacture properly, so verification of identity and bioactivity is critical.

Mechanism of Action (Research Context)

Binds and neutralizes TGF-beta superfamily ligands - principally myostatin (GDF-8) and activins - preventing their interaction with ActRIIB/ALK receptors and downstream SMAD2/3 signaling. Loss of myostatin signaling releases the brake on muscle satellite cell activity and protein synthesis.

Research Areas

Myostatin/activin signalingMuscle hypertrophy and wasting modelsReproductive endocrinologyMetabolic regulation research

Follistatin 344 Dosages in Research

1mg vials

Recombinant protein research material; animal studies typically use microgram-per-kilogram systemic dosing. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C or colder, desiccated. Reconstituted: 2-8C, use promptly; large glycoproteins are fragile - no vigorous agitation, avoid freeze-thaw cycles.

Follistatin 344 Supplier Price Comparison

No tracked suppliers stock Follistatin 344 yet — inventory syncs run continuously. Check our supplier reviews.

Follistatin 344 FAQ

It neutralizes myostatin and activins, the TGF-beta family proteins that suppress muscle growth. Animal models show large increases in muscle mass when myostatin signaling is blocked by follistatin.

They are splice isoforms: FST344 is the full-length circulating form with a C-terminal tail; FST315 is a shorter, more tissue-retained isoform with higher heparin binding. FST344 is the common research reagent.

A credible COA needs more than HPLC: look for SDS-PAGE/Western confirmation of the ~38 kDa band and ideally a bioactivity assay. Mass spec of a glycoprotein this size is specialist work.

Age & Use Verification