Dulaglutide: Research Profile, Dosages & Supplier Prices

GLP-1 agonist · Solution (pharmaceutical pen) / research lyophilisate · Also known as: Trulicity (brand), GLP-1-Fc fusion

Dulaglutide is a glp-1 agonist compound with a molecular weight of ~63 kDa (dimer) and a research half-life of ~5 days. Dulaglutide is a long-acting GLP-1 receptor agonist built as a fusion protein: a DPP-4-resistant GLP-1 analog linked to a modified IgG4 Fc fragment, giving antibody-like persistence with a half-life of about five days. It is an approved once-weekly pharmaceutical (Trulicity) for type 2 diabetes, with cardiovascular outcome data from the REWIND trial.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	GLP-1(7-37) analog fused to modified human IgG4 Fc via linker (disulfide-linked dimer)
Formula	Protein fusion construct
Mol. weight	~63 kDa (dimer)
Half-life	~5 days
Forms sold	Solution (pharmaceutical pen) / research lyophilisate

What is Dulaglutide?

In research, dulaglutide is a reference long-acting GLP-1 agonist used in metabolic, cardiovascular and renal studies, and a benchmark when comparing the newer multi-agonist peptides (tirzepatide, retatrutide). Its Fc-fusion architecture represents the protein-engineering approach to half-life extension, contrasting with the fatty-acid acylation strategy used by semaglutide and liraglutide.

Mechanism of Action (Research Context)

GLP-1 receptor agonist: glucose-dependent insulin secretion, glucagon suppression, delayed gastric emptying and central appetite effects. The IgG4 Fc domain provides FcRn-mediated recycling and the ~5-day half-life; DPP-4 resistance comes from amino-acid substitutions in the GLP-1 moiety.

Research Areas

GLP-1 receptor pharmacologyType 2 diabetes modelsCardiovascular outcome researchFc-fusion half-life engineering

Dulaglutide Dosages in Research

0.75mg1.5mg3mg4.5mg (clinical reference doses)

Approved clinical dosing is 0.75-4.5 mg once weekly. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

2-8C, do not freeze. Fc-fusion proteins are aggregation-sensitive - handle gently.

Dulaglutide Supplier Price Comparison

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Dulaglutide FAQ

Both are once-weekly GLP-1 agonists, but dulaglutide uses an IgG4 Fc fusion for half-life extension while semaglutide uses fatty-acid acylation (albumin binding). Semaglutide shows greater weight and glucose effects in head-to-head data.

Type 2 diabetes, cardiovascular outcomes (REWIND trial), and as a long-acting GLP-1 benchmark against newer multi-agonists like tirzepatide and retatrutide.

It is a GLP-1 analog fused to an antibody Fc fragment - a large recombinant fusion protein (~63 kDa), grouped with peptide agonists because its pharmacology is GLP-1 receptor mediated.

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