Dihexa: Research Profile, Dosages & Supplier Prices
Dihexa is a neuropeptide research compound with a molecular weight of 504.7 g/mol and a research half-life of long (days); orally stable. Dihexa is an orally active, blood-brain-barrier-penetrant peptidomimetic developed at Washington State University from angiotensin IV research. It potentiates hepatocyte growth factor (HGF) signaling at its receptor c-Met, and in preclinical models it has shown extraordinarily potent synaptogenic activity - reported as orders of magnitude more potent than BDNF at promoting new synaptic connections in vitro.
Research Use Only (RUO). Not for human or veterinary use. Not medical advice.
| Sequence | Hexanoyl-Tyr-Ile-Ahx-NH2 (peptidomimetic) |
| Formula | C27H44N4O5 |
| Mol. weight | 504.7 g/mol |
| Half-life | Long (days); orally stable |
| Forms sold | Lyophilized powder or solution |
What is Dihexa?
Research interest centers on cognitive repair models: Alzheimer's disease, Parkinson's disease, and general synaptic loss. Unlike most peptides, Dihexa is stable to digestion and effective orally in animal studies, which is rare for peptide-class compounds. It remains strictly preclinical - no human trials have been conducted - and its potent growth-factor pathway activity is itself an active safety research question.
Mechanism of Action (Research Context)
Binds hepatocyte growth factor (HGF) and potentiates HGF/c-Met receptor signaling, driving synaptogenesis and dendritic spine formation in hippocampal neurons. The c-Met pathway is implicated in learning, memory and neuronal repair.
Research Areas
Dihexa Dosages in Research
Animal cognition studies used oral milligram-per-kilogram-range dosing over weeks. No human dosing exists. Research-context only.
Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.
Storage & Handling
Lyophilized: -20C desiccated. In solution: 2-8C. Notably stable for a peptide-class compound, including to enzymatic digestion.
Dihexa Supplier Price Comparison
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